TODAY: Predicting the multi-omic Impact of GWAS Associations with Dr. Huckins

We are excited to be hosting Dr. Laura M. Huckins TODAY, Thursday, April 8, 2021, at 1 PM EDT. Don’t forget to register if you haven’t already! https://forms.gle/e4titjmtuEEQ7yj77

A bit more about Dr. Huckins’ research:
Abstract: The advent of large-scale, collaborative genome-wide association studies (GWAS) have yielded significant insights into the genetic architecture of complex traits, resulting in thousands of genome-wide significant loci associated with risk for hundreds of disorders. Now, researchers must move beyond this initial discovery stage to more fully understand the biological mechanisms underlying these traits and disorders. My research focuses on increasing our understanding of genetic regulation of higher order biology. Developing models and approaches to infer (for example) gene expression, histone modifications, and microbiome immediately and radically increases the power and impact of existing GWAS analyses, adding direction, tissue- and system-level resolution to genome- wide data. In this talk, I will describe our approach to predict genetically regulated gene expression (GREX) in human brain, and illustrate applications to elucidate aetiology of three psychiatric disorders; Schizophrenia, PTSD, and Anorexia Nervosa.

Associated papers:
Huckins, L. M. et al. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics 51, 659–674 (2019).
Huckins, L. M. et al. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Reports 31, 107716 (2020)
Johnson, J. S. et al. The Phenome-wide Consequences of Anorexia Nervosa Genes. Rev. (2021). MedRXivdoi:https://doi.org/10.1101/2021.02.12.21250941

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